Lean Wegovy when…
- Cardiovascular benefit is a priority — SELECT showed a 20% reduction in major CV events
- Your insurance covers Wegovy but not Zepbound
- You're already stable on semaglutide
HEAD TO HEAD
Wegovy vs Zepbound.
Wegovy (semaglutide 2.4 mg) and Zepbound (tirzepatide) are the two weekly injectables FDA-approved for chronic weight management. Zepbound showed greater average weight loss in its trial (SURMOUNT-1: up to 20.9% at 72 weeks) than Wegovy in its own (STEP-1: 14.9% at 68 weeks); Wegovy's molecule has dedicated cardiovascular outcome data (SELECT). Cost, coverage, and personal response usually decide — GLP AI tracks either.
Education only, from FDA labels and published trials — never medical advice. Which medication is right for you is a decision for you and your clinician.
VERIFIEDGLP AIWegovy vs ZepboundSources verified July 15, 2026
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FDA-labeledFacts from prescribing information, cited
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AT A GLANCE
When each one makes sense.
Lean Zepbound when…
- Maximum trial-measured weight loss is the goal (~21% vs ~15% averages)
- Nausea on semaglutide pushed you to try the alternative molecule
- Your plan's pricing favors Zepbound
These are talking points for a clinician conversation, not a prescription.
SIDE BY SIDE
Wegovy vs Zepbound, feature by feature.
| Wegovy | Zepbound | |
|---|---|---|
| Active ingredient | semaglutide | tirzepatide |
| Manufacturer | Novo Nordisk | Eli Lilly |
| FDA approval | FDA-approved for chronic weight management | FDA-approved for chronic weight management |
| Form & frequency | Injection, weekly | Injection, weekly |
| Dose range | 0.25 mg → 2.4 mg | 2.5 mg → 15 mg |
| Half-life | ~7 days | ~5 days |
| Headline trial result | Up to 14.9% mean body-weight reduction at 68 weeks (semaglutide 2.4 mg) | Up to 20.9% mean weight loss at 72 weeks on 15 mg (19.5% on 10 mg) |
| Most common side effect | Nausea (44%) | Nausea (25–29%) |
| Tracked by GLP AI | ✅ Doses, meals, side effects, levels | ✅ Doses, meals, side effects, levels |
Sources: Wegovy Prescribing Information (Novo Nordisk) · Zepbound Prescribing Information (Eli Lilly) · trials as cited on each medication's page.
WHICHEVER YOU CHOOSE
Track either with GLP AI.
Doses (shots or pills), a 0–100 GLP-1 Meal Score for every meal, side effects beside dose days, and an estimated medication level chart — the journey looks the same in GLP AI no matter which medication you and your clinician pick.
THE QUICK ANSWERS
Wegovy vs Zepbound — FAQs.
What is the difference between Wegovy and Zepbound?+
Wegovy (semaglutide 2.4 mg) and Zepbound (tirzepatide) are the two weekly injectables FDA-approved for chronic weight management. Zepbound showed greater average weight loss in its trial (SURMOUNT-1: up to 20.9% at 72 weeks) than Wegovy in its own (STEP-1: 14.9% at 68 weeks); Wegovy's molecule has dedicated cardiovascular outcome data (SELECT). Cost, coverage, and personal response usually decide — GLP AI tracks either.
How are Wegovy and Zepbound dosed?+
Wegovy: 0.25 mg → 0.5 mg → 1.0 mg → 1.7 mg → 2.4 mg, weekly (injection). Zepbound: 2.5 mg → 5 mg → 7.5 mg → 10 mg → 12.5 mg → 15 mg, weekly (injection). Escalation schedules come from each FDA label; your prescriber sets the pace.
How long do Wegovy and Zepbound stay in your system?+
Wegovy (semaglutide) has a ~7 days half-life; Zepbound (tirzepatide) has a ~5 days half-life. That difference shapes dosing frequency and how missed doses feel — GLP AI's medication level chart visualizes both.
Which has more side effects — Wegovy or Zepbound?+
Both are GI-first. Wegovy's label lists nausea at 44%; Zepbound's lists nausea at 25–29%. Cross-trial numbers aren't directly comparable, and individual tolerance varies — tracking your own timeline is more useful than comparing labels.
Can I switch between Wegovy and Zepbound?+
Switching between GLP-1 medications is common and is entirely a decision for your prescriber, who will map an equivalent starting dose. A tracked history — doses, side effects, weight — makes that conversation concrete.
Which is right for me — Wegovy or Zepbound?+
That's a clinical decision based on your health history, goals, tolerance, and coverage. This page is education, not medical advice. Whichever you and your clinician choose, GLP AI tracks it.
How do I track Wegovy or Zepbound?+
GLP AI tracks both: doses (shots or pills), a 0–100 GLP-1 Meal Score for every meal, side effects beside dose days, and an estimated medication level chart — one timeline either way.
Do Wegovy and Zepbound have different side effects?+
The side-effect profile is similar — GI-first (nausea, diarrhea, constipation) with the same serious-symptom warnings. Reported frequencies differ by trial: Wegovy's label lists nausea at 44%; Zepbound's at 25–29%. Cross-trial numbers aren't directly comparable, but tolerance genuinely varies by person and molecule.
KEEP EXPLORING
Go further with GLP AI.
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Whichever medication wins, GLP AI tracks it — free to start.